More than 3,000,000 babies are born with serious genetic defects every year, with a majority in developing countries. We combine statistical learning and high-throughput sequencing. Our novel technology can detect disorders such as thalassemia through a simple blood test. As the fetus develops, a small number of fetal cells dies, and their DNA molecules enter into the maternal bloodstream. BillionToOne has developed an accurate molecular counter that takes advantage of the freely circulating fetal DNA to determine whether the fetus has genetic disorders. Our focus on quantitative biology and statistical learning methods allows us to optimize for signal-to-noise ratio, thereby decreasing sequencing costs and making it possible to detect even single-gene disorders. Thus, only our novel technology can accurately detect disorders such as cystic fibrosis, sickle-cell anemia, and thalassemia through a simple blood test. Thalassemia is an endemic problem in many developing countries including India, where it is seen in ~3% of all births.